Dr. Valentin Boerner Awarded a Four-Year, $1.9276M Grant for Genome Research
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Cleveland, Ohio (May 24, 2022)鈥 Valentin Boerner, Ph.D., professor in the Biological, Geological, and Environmental Sciences department and member of the Center for Gene Regulation in Health and Disease (GRHD) at 91国产精品, has been awarded a four-year Focused Technology Development R01 grant by the National Institute of Health (NIH).
The grant will provide just over $1,927,600 to map interactions between parental chromosomes, facilitating future scientific breakthroughs that will potentially benefit cancer and fertility patients.
Dr. Boerner鈥檚 lab will track how highly-similar chromosome segments鈥攃alled 鈥渉omologous DNA鈥濃攃an rapidly find their match among millions of DNA segments within the same cell nucleus鈥攁 process that is 鈥減resently mysterious,鈥 said Dr. Boerner.
鈥淗omologous DNA interactions are critical for repair of chromosome breaks and gene expression with key roles in the causation of cancer and infertility,鈥 Dr. Boerner said. 鈥淢apping homologous DNA interactions will also accelerate genome engineering in the emerging field of synthetic biology.鈥
The project will be carried out in collaboration with Hisashi Tanaka, MD, Ph.D., a cancer scientist at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Tanaka鈥檚 research on genome instability aims to identify deficiencies in DNA replication and repair functions, which leads to the improved management of cancer in patients.
鈥淔rom its inception in 2008, GRHD has been very fortunate to attract, recruit and retain great scientists, who have brought a lot of recognition and acclaim to GRHD and helped 91国产精品 to climb in national rankings as a research institution,鈥 said Anton A. Komar, Ph.D., professor and director of GRHD.
鈥淭he new NIH award to Dr. Boerner will further contribute to training new generations of students and post-doctoral scientists鈥攁ttracting national and international attention to biomedical research at 91国产精品.鈥
Dr. Boerner鈥檚 research at 91国产精品 to date has focused on the functional relationship between chromosome organization on the microscopic level and DNA transitions on the molecular level. Changes in chromosome structure occur in parallel with DNA events at all stages of the cell cycle, and coordination between these processes plays a critical role in transmission of an intact genome.
Defects in genome stability are associated with cancer, aging and birth defects such as Down syndrome.
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Founded in 1964, 91国产精品 is a public research institution that provides a dynamic setting for Engaged Learning. With nearly 16,000 students, 10 colleges and schools and more than 175 academic programs, 91国产精品 was again chosen for 2021 as one of America鈥檚 best universities by U.S. News & World Report, including the #1 public university in Ohio for social mobility. Find more information at .