91¹ú²ú¾«Æ·

Dr. Sun’s laboratory is working in Medicinal and Pharmaceutical Chemistry and Chemical Biology area.

We are interested in cell surface and receptors’ glycosylation patterns and changes under pathological pathways. One major research project is developing novel chemical probes and enzyme inhibitors to profile and modulate sialylaion and desialylation of receptor proteins in immune cells, including monocytes and macrophages related to infection, immune response and inflammation. The long-term goal of this research is to discover the sialylation molecular mechanisms in infection, immune response and inflammation and identify novel targets and lead compounds for antiviral infection and anti-inflammation drug development for flu and coronavirus infection and sepsis.

• Yang D, Wu Y, Turan I, Keil J, Li K, Chen MH, Liu R, Wang L, Sun XL, Chen GY. Targeting intracellular Neu1 for Coronavirus Infection Treatment. iScience, 2023, 26, 106037.
• Keil JM, Rafn GR, Turan IM, Aljohani MA, Sahebjam-Atabaki R, Sun XL. Sialidase Inhibitors with Different Mechanisms. J Med Chem (Perspective Review) 2022, 65, 13574-13593.
• Zhao Y, Mahajan G, Kothapalli CR, Sun XL. Sialylation status and mechanical properties of THP-1 macrophages upon LPS stimulation. Biochem Biophys Res Commun. 2019, 518(3):573-578.
• Whited J, Zhang X, Nie H, Wang D, Li Y, Sun XL. Recent Chemical Biology Approaches for Profiling Cell Surface Sialylation Status. ACS Chem Biol. 2018, 13(9):2364-2374.
• Wang D, Ozhegov E, Wang L, Zhou A, Nie H, Li Y, Sun XL. Sialylation and desialylation dynamics of monocytes upon differentiation and polarization to macrophages. Glycoconj J. 2016 Oct;33(5):725-33.

In addition, we are interested in biomimetic synthesis of native biomolecule thrombomodulin (TM) for the compensation of its loss in the pathological site, as an on-demand anticoagulant and anti-inflammatory therapeutic strategy. Specifically, we are developing TM-liposome conjugates that mimic the native endothelial antithrombotic mechanism of both TM and lipid components and thus will provide a more forceful antithrombotic agent. Also, we are developing TM-glycosaminoglycan (GAG) conjugates and investigating the significance of GAG on the antithrombotic activity and pharmacokinetic properties of TM.

• Gruzdys V, Wang L, Wang D, Huang R, Sun XL. Investigation of cofactor activities of endothelial microparticle-thrombomodulin with liposomal surrogate. Biochem Biophys Res Commun. 2023, 651:79-84.
• Boron M, Hauzer-Martin T, Keil J, Sun XL. Circulating Thrombomodulin: Release Mechanisms, Measurements, and Levels in Diseases and Medical Procedures. TH Open. 2022, 6(3):e194-e212.
• Liu X, Boron M, Zhao Y, Sun XL. End-point modification of recombinant thrombomodulin with enhanced stability and anticoagulant activity. Eur J Pharm Sci. 2019, 139, 105066.
• Wang L, Jiang R, Liu Y, Cheng M, Wu Q, Sun XL. Recombinant and chemo-/bio-orthogonal synthesis of liposomal thrombomodulin and its antithrombotic activity. J Biosci Bioeng. 2017, 124(4):445-451.
• Wang L, Jiang R, Wang L, Liu Y, Sun XL. Preparation of chain-end clickable recombinant protein and its bio-orthogonal modification. Bioorg Chem. 2016, 65:159-66.

Furthermore, we are developing biomimetic glycoligands for microarray, carbon nanotube, quantum dot and liposome surface functionalization for biosensor and drug delivery applications. In particular, we are making macro-glycoligands with native glycans in native linkage, in controlled density and orientation for both specificity and affinity.

• DiLillo AM, Chan KK, Sun XL, Ao G. Glycopolymer-Wrapped Carbon Nanotubes Show Distinct Interaction of Carbohydrates with Lectins. Front Chem. 2022, 10:852988.
• Sonia Tomar and Xue-Long Sun*, Carbohydrate Functionalized Liposomes and Applications, Comprehensive Glycoscience, 2nd edition, Editor Joseph J. Barchi, 2021, Page 370-379.
• Bigdelou P, Chan KK, Tang J, Yu KN, Whited J, Wang D, Lee MY, Sun XL. High-throughput multiplex assays with mouse macrophages on pillar plate platforms. Exp Cell Res. 2020, 396, 112243.
• Chan KK, Lei Q, Tang J, Sun XL. Synthesis of aryl azide chain-end functionalized N-linked glycan polymers and their photo-labelling of specific protein. RSC Adv. 2020, 10(63):38561-38565.
• Tang J, Ozhegov E, Liu Y, Wang D, Yao X, Sun XL. Straightforward Synthesis of N-Glycan Polymers from Free Glycans via Cyanoxyl Free Radical-Mediated Polymerization. ACS Macro Lett. 2017, 6(2):107-111.

Our research has been supported by NIH RO1 and R15 grants, AHA research grant, NSF research grant, 91¹ú²ú¾«Æ· Startup Fund and Internal Grants. Many Thanks!

Dr. Horoaki Sasaki
Visiting Scholar

Isaac Turan
Ph.D. Graduate Student

Majdi A Aljohani
Ph.D. Graduate Student

Reza Sahebjam-Atabaki
Ph.D. Graduate Student

Sophie J McIntyre
Undergraduate Student

Jonathan Nitardy
Undergraduate Student

Book:
Methods in Molecular Biology 1367: Macro-Glycoligand Methods and Protocols, Xue-Long Sun Editor (ISBN 978-1-4939-3130-9,Springer Science), 2016

Peer-Reviewed Research Articles and Book Chapters
2023
124. Brandon Heppe, Nina Dzombic, Joseph Keil, Xue-Long Sun*, Geyou Ao*. Solvent Isotope Effects on the Creation of Fluorescent Quantum Defects in Carbon Nanotubes by Aryl Diazonium Chemistry, J. Am. Chem. Soc. 2023, accepted.
123. Valentinas Gruzdys, Lin Wang, Dan Wang, Rachel Huang, and Xue-Long Sun*. Investigation of Cofactor Activities of Endothelial Microparticle-Thrombomodulin with Liposomal Surrogate. Biochemical and Biophysical Research Communications 2023, 651, 79-84.
122. Darong Yang, Yin Wu, Isaac Turan, Joseph Keil, Kui Li, Michael H Chen, Runhua Liu, Lizhong Wang, Xue-Long Sun*, Guo-Yun Chen*. Targeting intracellular Neu1 for Coronavirus Infection Treatment. iScience, 2023, 26(2), 106037.

2022
121. Joseph M. Keil, Garrett R. Rafn, Isaac M. Turan, Majdi A. Aljohani, Reza Sahebjam-Atabaki, Xue-Long Sun*, Sialidase Inhibitors with Different Mechanisms, Journal of Medicinal Chemistry (Perspective Review) 2022, 65, 13574-13593.
120. Darong Yang, Yin Wu, Isaac Turan, Joseph Keil, Kui Li, Michael H Chen, Runhua Liu, Lizhong Wang, Xue-Long Sun*, Guo-Yun Chen*. Targeting intracellular Neu1 for Coronavirus Infection Treatment. bioRxiv 2022.09.09.507342; doi: .
119. Mallorie Boron, Tiffany Hauzer-Martin, Joseph Keil and Xue-Long Sun*, Circulating Thrombomodulin (TM): Release Mechanisms, Measurements and Levels in Diseases and Medical Procedures, Thrombosis and Haemostasis Open 2022, 6, e194-e212.
118. Ana M. DiLillo, Ka Keung Chan, Xue-Long Sun*, and Geyou Ao*. Glycopolymer-Wrapped Carbon Nanotubes Show Distinct Interaction of Carbohydrates with Lectins. Frontiers in Chemistry - Chemical Biology, 2022, 10, 852988.

2021
117. Xue-Long Sun*, The Role of Cell Surface Sialic Acids for SARS-CoV-2 Infection. Glycobiology 2021, cwab032, .
116. Sonia Tomar and Xue-Long Sun*, Carbohydrate Functionalized Liposomes and Applications, Comprehensive Glycoscience, 2nd edition, Editor Joseph J. Barchi, 2021, Page 370-379.

2020
115. Ka Keung Chan, Qiaoshi Lei, Jinshan Tang, Xue-Long Sun*. Synthesis of Aryl Azide Chain-end Functionalized N-Linked Glycan Polymer and Its Photo-labeling of Specific Protein, RSC Advances 2020, 10, 38561-38565.
114. P. Bigdelou, K.K. Chan, J. Tang, K.-N.Yu, J. Whited, D. Wang, M.-Y. Lee* and Xue-Long Sun*. High-throughput multiplex assays with mouse macrophages on pillar plate platforms, Experimental Cell Research 2020, 396, 112243.
113. L. Yuan, Y. Zhao, Xue-Long Sun* Sialidase Substrates for Sialdiase Assays - Activity, Specificity, Quantification and Inhibition, Glycoconjugate Journal 2020, 37, 513-531.
112. Michael A. Cantwell, Ka Keung Chan, Xue-Long Sun*, Geyou Ao*, Carbohydrate Identity and Polymer Chain Length of Glycopolymers Show Synergistic Effects on Dispersing Carbon Nanotubes. Langmuir 2020, 33, 9878-9885.
111. S. Tamar, Xue-Long Sun*. Investigation of Substrate Specificity of Sialidases with Membrane Mimetic Glycoconjugates. Glycoconjugate Journal 2020, 37, 175-185.

2019
110. X. Liu, M. Boron, Y.Zhao, Xue-Long Sun*. End-point Modification of Recombinant Thrombomodulin with Enhanced Stability and Anticoagulant Activity, European Journal of Pharmaceutical Sciences 2019, 139, 105066.
109. Y. Zhao, G. Mahajan, C. R. Kothapalli*. Xue-Long Sun*. Investigation of Sialylation and Mechanical Properties of THP-1 Macrophages upon LPS Stimulation. Biochem. Biophys. Res. Commun. 2019, 518, 573-578.
108. D.-m. Tian, J. Qiao, Y.-z. Bao, J. Liu, X.-k.  Zhang, Xue-Long Sun, Y.-w. Zhang, X.-s. Yao, J.-s. Tang. Design and synthesis of biotinylated cardiac glycosides for probing Nur77 protein inducting pathway. Bioorg. Med. Chem, Lett. 2019, 29, 707-712

2018
107. Xue-Long Sun.* Chemical Regulation of Glycosylation Processes. Trends in Glycoscience and Glycotechnology (TIGG) 2018, 30, E179-193.
106. X. Zhang, H. Nie, J. Whited, D. Wang, Y. Li, Xue-Long Sun.* Recent Bio-Affinity Approaches for Directly Profiling Cell Surface Sialoform. Glycobiology 2018, 28, 910-924.
105. J. Whited, C. K. Rama, Xue-Long Sun.* Synthesis and Evaluation of Protein-Phenylboronic Acid Conjugates as Lectin Mimetics. ACS Omega 2018, 3, 13467-13473.
104. J. Whited, X. Zhang, H. Nie, D. Wang, Y. Li and Xue-Long Sun.* Recent Chemical Biology Approaches for Profiling Cell Surface Sialylation Status. ACS Chemical Biology 2018, 13, 2364-2374.
103. H. Wang, S. Li. J. Wang, S. Chen, Xue-Long Sun, Q. Wu. N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding. eLife 2018, 7:e35672.
102. P. Vabbilisetty, M. Boron, H. Nie, E. Ozhegov, Xue-Long Sun.* Chemical Reactive Anchoring Lipids with Different Performance for Cell Surface Re-Engineering Application. ACS Omega, 2018, 3, 1589-1599.
101. X. Li, Y. Ren, Y. Bao, J. Liu, X. Zhang, Xue-Long Sun, X. Yao, J. Tang. Synthesis of C3-Neoglycosides of Digoxigenin and Their Anticancer Activities. European Journal of Medicinal Chemistry, 2018, 145, 252-262.  

2017
100. L. Wang, R.Jiang, Y.Liu, M. Cheng, Q. Wu, Xue-Long Sun.* Recombinant and Chemo-/Bio-Orthogonal Synthesis of Liposomal Thrombomodulin and Its Antithrombotic Activity, Journal of Bioscience and Bioengineering, 2017, 124, 445-451.
99. D. Wang, X. Li, Y. Bao, J. Liu, X. Zhang, X.Yao, Xue-Long Sun, J. Tang. Synthesis of MeON-Neoglycosides of digoxigenin with 6-deoxy- and 2,6-dideoxy-d-glucose derivatives and their anticancer activity. Bioorg. Med. Chem. Lett. 2017, 27, 3359-3364.
98. J. Tang, E. Ozhegov, Y. Liu, D. Wang, X. Yao,  Xue-Long Sun.* Straightforward Synthesis of N-Glycan Polymers from Free Glycans via Cyanoxyl Free Radical-mediated Polymerization, ACS MacroLetters, 2017, 6, 107-111.

2016
97. D. Wang, E. Ozhegov, L. Wang, A. Zhou, H. Nie, Y. Li, Xue-Long Sun,* Sialylation and Desialylation Dynamics of Monocytes upon Differentiation and Polarization to Macrophages, Glycoconjugate J. 2016, 33, 725-733.
96. L. Wang, R. Jiang, L. Wang, and Xue-Long Sun,* Incorporation of Azide Functionality into Recombinant Protein via Recombinant, Enzymatic, and Chemical Approaches for Bio-Orthogonal Modification, Bioorganic Chemistry 2016, 65, 159-166.
95. H. Zhang, J. Weingart, V. Gruzdys, Xue-Long Sun,* Synthesis of an End-to-End Protein-Glycopolymer Conjugate via Bio-Orthogonal Chemistry. ACS MacroLetters, 2016, 5, 73-77.
94. L. Wang, Y. Liu, L. Wu, Xue-Long Sun*, Sialyltransferases Inhibition and Recent Advances, BBA - Proteins and Proteomics, 2016, 1864, 143-153.

2015
93. H. Nie, X. Liu, Y. Zhang, T. Li, C. Zhan, Y. Yao, Y. Jin, Y. Qu, Xue-Long Sun and Yu Li, Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-alpha-1, 6-fucosylated Triantennary Glycan via Nacetylglucosaminyltransferases-IVa Regluation, Scientific Report 2015, 5, 16007.
92. D. Wang, H. Nie, E. Ozhegov, A. Zhou, Y. Li, Xue-Long Sun*. Globally Profiling Sialylation Status of Macrophages upon Statin Treatment. Glycobiology 2015, 25, 1007-1015.
91. S. Nandana Narla and Xue-Long Sun,* Oriented Immobilized Sialyloligo-Macroligand Methods and Protocols, Microarray. Chapter 16, Page 195-206, Methods in Molecular Biology 1367: Macro-Glycoligand , Xue-Long Sun Editor (Humana Press/Springer Science), 2015.
90. V. Gruzdys, Jinshan Tang, E. L. Chaikof, Xue-Long Sun,* Facile Synthesis of Chain-End Functionalized Glycopolymers (CMFRP), Chapter 1, 3-12, Methods in Molecular Biology 1367: Macro-Glycoligand Methods and Protocols, Xue-Long Sun Editor (Humana Press/Springer Science), 2015.
89. S. N. Narla, H. Nie, Y. Li, Xue-Long Sun,* Multi-dimensional glycan microarrays with glyco-macroligands, Glycoconjugate Journal 2015, 32, 483-495.
88. W. Cui, K Khan, C Desai, T Fishbein, XL Sun, H Wu,  H. Jun, E. Kharlampieva, H.M. Tse, Y. Zhu, H. Wang, E. Chaikof, Multidisciplinary Approaches to Islet Transplantation, CellR4 2015, 3, e1388.
87. J. Weingart, P. Vabbilisetty, Xue-Long Sun*, Glyco-functionalized Liposomes. Chapter 8, Page 211-232, Carbohydrate Nanotechnolggy (Editor: Keith Stine, John Wiley & Sons, Inc), 2015.

2014
86. L. Wang, D. Wang, X. Zhou, L. Wu, Xue-Long Sun*, Systemic Investigation on Quinoxaline Derivatization of Sialic Acid and Its Quantitative Application for Biosamples. RSC Advances, 2014, 4, 45797-45803.
85. L. Wang, V. Gruzdys, N. Pang, F. Meng, Xue-Long Sun*, Primary Arylamine-Based Tyrosine-Targeted Protein Modification. RSC Advances, 2014, 4, 39446-39452.
84. V.Gruzdys, H. Zhang,Xue-Long Sun*, Glyco-modification of protein with O-cyanate chain-end functionalized glycopolymer via isourea bond formation. Journal of Carbohydrate Chemistry 2014, 7-8, 368-380.
83. P. Vabbilisetty, Xue-Long Sun*, Liposome Surface Functionalization Based on Different Anchoring Lipids via Staudinger Ligation, Organic and Biomolecular Chemistry 2014, 12, 1237-1244..
82. S. Narla, P. Pinnamaneni, H. Nie, Y. Li, Xue-Long Sun*, BSA-boronic acid conjugate as lectin mimetics, Biochemical and Biophysical Research Communications 2014, 443, 562-567.
81. D. Wang, X. Zhou, L. Wang, S. Wang, Xue-Long Sun*, Quantification of free sialic acid in human plasma through a robust quinoxalinone derivatization and LC-MS/MS using isotope-labeled standard calibration, J. Chromatography B 2014, 944, 75-81.
80. R. Jiang, L. Wang, J. Weingart,Xue-Long Sun* Chemo-Enzymatic Bioorthogonal Chemistry for Site-Specific Double Modification of Recombinant Thrombomodulin, ChemBioChem - A European Journal of Chemical Biology, 2014, 15, 42-46.
79. L. Wang, R. Jiang, Xue-Long Sun*, Recombinant Thrombomodulin with Different Domains for Pharmaceutical, Biomedical and Cell Transplantation Applications, Medicinal Research Reviews 2014, 34, 479-502.

2013
78. J. Weingart, P. Vabbilisetty, Xue-Long Sun*, Membrane mimetic surface functionalization of nanoparticles: Methods and applications. Advances in Colloid and Interface Science 2013 197-198, 68-84.
77. Xue-Long Sun*, Glycosyltransferases as Potential Drug Targets. Medicinal Chemistry  2013, 3, e106.
76. H. Zhang, Jacob J. Weingart, R. Jiang, J. Peng, Q, Wu, Xue-Long Sun*, Syntheses of Bio-Inspired Thrombomodulin Conjugate through Bioorthogonal Chemistry. Bioconjugate Chemistry 2013, 24, 550-559.

2012
75. Xue-Long Sun*, Cellular Glycomics: Strategies and Approaches. Journal of Glycomics and Lipidomics  2012, 2, e105.
74. Y. Ma, I. Sobkiv, V. Gruzdys, H. Zhang and Xue-Long Sun*, Liposomal glyco-microarray for studying glycolipid-protein interactions. Analytical and Bioanalytical Chemistry 2012, 404, 51-58.
73. S. N. Narla and Xue-Long Sun*, Immobilized Sialyloligo-Macroligand and Its Protein Binding Specificity. Biomacromolecules 2012, 13, 1675-1682.
72. H. Nie, Y. Li, Xue-Long Sun*, Recent Advances in Sialic Acid-Focused Glycomics. Journal of Proteomics 2012, 75, 3098-3112.
71. R. Jiang, J. Weingart and Xue-Long Sun* End-Point Immobilization of Recombinant Thrombomodulin via Sortase-Mediated Ligation, Bioconjugate Chem. 2012, 23, 643-649.
70. S. N. Narla, Xue-Long Sun*, Glyco-Macroligand Microarrays with Controlled Glycan Density and Orientation. Lab on Chip, 2012, 12, 1656-1663.  
69. X. Zeng, C. A. S. Andrade, M. D. L. Oliveira, Xue-Long Sun. Carbohydrate-protein interactions and their biosensing applications. Analytical and Bioanalytical Chemistry 2012, 402, 3161-3176.
68. Y. Ma, R. Jiang, H. Zhang and Xue-Long Sun*, Chemoselective Funtionalizable Tethered Bilayer Lipid Membrane for Versatile Membrane Mimetic Systems Fabrication. Journal of Materials Chemistry 2012, 22, 6148-6155.
67. S. N. Narla, H. Nie, Y. Li, Xue-Long Sun*, Recent Advances in Synthesis and Biomedical Applications od Chain-End Functionalized Glycopolymers. J. Carbohydrate Chem. 2012, 32, 67-92.

2011
66. J. Weingart, Xue-Long Sun*, "Glyco-Functionalized Quantum Dots- in ACS Symposium Book Series - Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicines" edited by Xuefei Huang and Joseph Barch, 2011, Volume 1091, Chapter 7, Page 105-121.  
65. Y. Ma, H. Zhang and Xue-Long Sun*, Azide-Reactive Liposome for Chemoselective and Biocompatible Liposomal Surface Functionalization and Glyco-Liposomal Microarray Fabrication, Langmuir 2011, 27, 13097-13103.
64. J. Peng, J. Jiang, W. Wang, X. Qi, Xue-Long Sun, Q. Wu, Glycosylation and Processing of Pro-B-type Natriuretic Peptide in Cardiomyocytes. Biochem. Biophys. Res. Commun. 2011, 411, 593-598.
63. H. Zhang, Y. Ma, Xue-Long Sun*, ¿Chemical Selective and Biocompatible Liposome Surface Functionalization Approach¿ Chapter 16 in Methods in Molecular Biology Book Series: Bioconjugation Protocols, 2nd Ed. Sonny S. Mark Editor (Humana Press/Springer Science), 2011.
62. S. N. Narla, Xue-Long Sun*, Synthesis of Orientated Glyco-Macroligand Based on Site-Specific Immobilization of Chain-End Functionalized Glycopolymer. Organic and Biomolecular Chemistry 2011, 9, 845-850.

2010
61. Y. Ma, H. Zhang and Xue-Long Sun*, Spherical Glycosurface Assembling Based on Chemoselcetive and Biocompatible Immobilization and Further Modification of Intact Liposome. Bioconjugate Chemistry 2010, 21, 1994-1999.
60. Y. Wang, S. Chalagalla, T. Li, Xue-Long Sun, W. Zhao, P. Wang, X. Zeng, Label Free Carbohydrate Biosensors Based on Polyvalent Interaction for Sensitivity Amplification. Biosensors and Bioelectronics 2010, 26, 996-1001.
59. S. Chalagalla, Y. Wang, D. Ray, X. Zeng and Xue-Long Sun*, Synthesis and Characterization of Oriented Glyco-Capturing Macroligand. ChemBioChem 2010, 11, 2018-2025.
58. Xue-Long Sun, Preface for Special Issue of Carbohydrate Recognition and Applications for Medicinal Research Reviews, 2010, 30 (2), 169-170.
57. H. Zhang, Y. Ma, Xue-Long Sun*, Recent Carbohydrate Recognition Based Targeted Drug and Gene Delivery. Medicinal Research Review, 2010, 30, 270-289.
56. S. Chalagalla, Xue-Long Sun*, Synthesis and Characterization of Biotin Chain-End Functionalized Boropolymer as Functional Glyco-Affinity Macroligand, Reactive and Functional Polymers 2010, 70, 471-476.

Before 2009
55. H. Zhang, Y. Ma, Xue-Long Sun*, Chemical Selective Surface Glyco-Functionalization of Liposome through Staudinger Ligation. Chemical Communications, 2009, 3032-3034.
54. Xue-Long Sun, Functional Glyco-Affinity Precipitation for Enhanced Glyco-Proteomics. Current Proteomics, 2008, 5, 202-210.
53. Xue-Long Sun*, L. Yang, and E. L. Chaikof, Chemical Selective Immobilization of Biomolecules through Aqueous Diels-Alder and PEG Chemistry, Tetrahedron Letter, 2008, 49, 2510-2513.
52. C. Stabler, Xue-Long Sun, W. Cui, J. Wilson, C. Haller, and E. L. Chaikof, Surface Re-Engineering of Pancreatic Islets, Bioconjugate Chemistry 2007, 18, 1713-1715.
51. Xue-Long Sun, Recent Multivalent Sialyloligosaccharide and Sialylmimetics-Based Antiinfluenza Strategies. Current Medicinal Chemistry 2007, 14, 2304-2313.  

Peer-Reviewed Publications at Emory University:
50. J. T. Wilson, W. Cui, Xue-Long Sun, C. T. Tucker-Burden, C. J. Weber, E. L. Chaikof, In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film. Biomaterials 2007, 28, 609-617.
49. S. W. Jordan, K. M. Faucher, J. Caves, R. A. Apkarian, S. M. Rele, Xue-Long Sun, S. R. Hanson E. L. Chaikof, Fabrication of a self-assembled membrane-mimetic thin film on a PTFE vascular graft surface. Biomaterials 2006, 27, 3473-3481.
48. Xue-Long Sun*, N. Biswas, T. Kai, K. Z. Dai, R. A. Dluhy, and Elliot L. Chaikof, Synthesis and Self-Assemblies of Asymmetric Lipid Bolaamphiphile, Langmuir 2006, 22, 1201-1208.
47. P. Tseng, S. W. Jordan, Xue-Long Sun, E. L.Chaikof, Catalytic efficiency of a thrombomodulin-functionalized membrane-mimetic film in a flow model. Biomaterials 2006, 27, 2768-2775.
46. P. Tseng, S. M. Rele, Xue-Long Sun, E. L. Chaikof, Fabrication and characterization of heparin functionalized membrane-mimetic assemblies. Biomaterials 2006, 27, 2627-2636.
45. P. Tseng, S. M. Rele, Xue-Long Sun, E. L. Chaikof, Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor induced thrombin generation in a flow model. Biomaterials 2006, 27, 2637-2650.
44. E. L. Chaikof, P. Tseng, S.M. Rele, S.W. Jordan and Xue-Long Sun, Surface bound thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model. J. Surg. Res. 2006, 130, 203-204.
43. Xue-Long Sun*, C. Stabler, C. Cazalis, E. L. Chaikof, Carbohydrates and Protein Immobilization onto Solid Surface by Sequential Diels-Alder and Azide-Alkyne Cycloaddition, Bioconjugate Chem. 2006, 17, 52-57.
42. Xue-Long Sun*, C. Haller, X. Wu, and Elliot L. Chaikof, One-Pot Glyco-Affinity Precipitation Purification: The Flexible Alignment of Solution-Phase Capture/Release and Solid-Phase Separation. J. Proteome Res. 2005, 4, 2355-2359.
41. T. Kai, Xue-Long Sun*, K. M. Faucher, and Elliot L. Chaikof, Design and Synthesis of Asymmetric Acyclic Phospholipid Bolaamphiphiles, J. Org. Chem. 2005, 70, 2606-2615.
40. Xue-Long Sun, ChemMedChem (European Jorunal of Medicinal Chemistry, Wiley Interscience), 2005, 1, 159. Book Review: ¿Biopolymers for Medical and Pharmaceutical Applications¿. Ed. Alexander Steinbüchel and Robert H. Marchessault, 1145pp, ISBN 3527311548, Wiely-VCH, 2005.
39. M. Murphy, K. M. Faucher, Xue-Long Sun, E. L. Chaikof and R. A. Dluhy, Analysis of photoinitiated polymerization in a membrane mimetic film using infrared spectroscopy and near-IR Raman microscopy. Colloids and Surface B: Biointerface 2005, 46, 226-232.
38. R. Guan, Xue-Long Sun, D. Grande, S. Baskaran, and E. L. Chaikof, A Glycopolymer Chaperone for Fibroblast Growth Factor-2, Bioconjugate Chem. 2004, 15, 145-151.
37. C.-M. Dong, Xue-Long Sun, K. M. Faucher, R. P. Apkarian, and Elliot L. Chaikof, Design, Synthesis and Characterization of Glycopolymer-Polypeptide Triblock Copolymers, Biomacromolecules, 2004, 5, 224-231.
36. Xue-Long Sun*, W. Cui, T. Kai, and E. L. Chaikof, A Facile Synthesis of Bifunctional Phospholipids for Biomimetic Membrane Engineering, Tetrahedron 2004, 60, 11765-11770.
35. Xue-Long Sun*, W. Cui, C. Haller, and E. L. Chaikof, Site-Specific Multivalent Carbohydrate-Labeled Quantum Dots and Magnetic Beads, ChemBioChem 2004, 5, 1593-1596.
34. S. Hou, Xue-Long Sun*, C.-H. Dong, and E. L. Chaikof, Facile Synthesis of Chain-End Functionalized Glycopolymers for Site-Specific Bioconjugation, Bioconjugate Chem. 2004, 15, 954-959.
33. K. Faucher, Xue-Long Sun, and E. L. Chaikof, Fabrication and Characterization of Glycocalyx-Mimetic Surface, Langmuir 2003, 19. 1664-1670.
32. Xue-Long Sun,* K. M. Faucher, M. Houston, D. Grande, and E. L. Chaikof, Design and Synthesis of Biotin-Terminated Glycopolymer for Surface Glycoengineering, J. Am. Chem. Soc. 2002, 124, 7258-7259.
31. Xue-Long Sun, D. Grande, S. Baskaran, and E. L. Chaikof, Glycosaminoglycan-Mimetic Biomaterials 4: Synthesis of Sulfated Lactose-Based Glycopolymers that Exhibit Anticoagulant Activity, Biomacromolecules 2002, 3, 1065-1070.
30. J. Feng, P. Y. Tseng, K. M. Faucher, J. M. Orban, Xue-Long Sun, and E. L. Chaikof, Functional Reconstitution of Thromobomodulin with a Substrated Membrane-Mimetic Polymer Film, Langmuir 2002, 18, 9907-9913.
29. Xue-Long Sun, Keith M. Faucher and Elliot L. Chaikof, ¿Cytomimetic Biomaterials: Fabrication, Characterization and Applications¿ in ¿Biomimetic Materials and Design: Interactive Biointerfacial Strategies, Tissue Engineering, and Target Drug Delivery¿. Chapter 5, pp139-157, Dillow, A. K. and Lowman, A. Eds. Marcel-Dekker, Inc. Publisher. August 2002.
28. S. Baskaran, D. Grande, Xue-Long Sun, A, Yayon, and E. L. Chaikof, Glycosaminoglycan-Mimetic Biomaterials 3: Glycopolymers Prepared from Alkene-Derivatized Mono- and Disaccharide-Based Glycomonomers, Bioconjugate Chem. 2002, 13, 1309-1313.
27. H. Liu, K. M. Faucher, Xue-Long Sun, J. Feng, J. M. Orban, and E. L. Chaikof, A Supported Lipid Bilayer as a Membrane-Mimetic Cell Encapsulation Barrier, Langmuir 2002, 18,1332-1339.
26. Xue-Long Sun, H. Liu, J. M. Orban, L. Sun, and E. L. Chaikof, Synthesis and Terminal Functionalization of Polymerizable Phosphatidyl ethanolamine, Bioconjugate Chem. 2001, 12, 673-677.

Peer-Reviewed Publications at Riken Institute:
25. H. Hinou, Xue-Long Sun, and Y. Ito, Systematic Synthesis and Inhibitory Activity of Bisubstrate-Type Inhibitors of Sialyltransferases, J. Org. Chem. 2003, 68, 5602-5613.
24. H. Hinou, Xue-Long Sun, and Y. Ito, Bisubstrate-Type Inhibitors of Sialyltransferase, Tetrahedron. Lett. 2002, 43. 9147-9150.
23. C.-T. Guo, Xue-Long Sun, O. Kanie, K. F. Shotridge, T. Suzuki, D. Miyamoto, K. I.-P. Hidari, C.-H. Wong, and Y. Suzuki, A Discovery of An O-Glycoside of Sialic Acid Derivative That Inhibits both Hemagglutinin and Sialidase of Human Influenza Virus, Glycobiology 2002, 12, 183-190.
22. Xue-Long Sun, Y. Kanie, C.-T. Guo, O. Kanie, Y. Suzuki, and C.-H. Wong, Syntheses of C-3 Modified Sialylglycosides as Inhibitors of Influenza Hemagglutinin and Neuraminidase, Eur. J. Org. Chem. 2000, 14, 2643-2653.
21. Xue-Long Sun, Pharmacia (Journal of the Pharmaceutical Society of Japan), 1999, 35, 1165-1166. Article Review: K. Oshima, Y. Aoyama, Regiospecific Glycosidation of Unprotected Sugars via Arylboronic Activation. J. Am. Chem. Soc. 1999, 121, 2315-2316.

Peer-Reviewed Publications at Kitasato University:
20. Xue-Long Sun, N. Sato, T. Kai, and K. Furuhata, Novel Practical Synthesis of 2,6-Anhydro-3- eoxy-D-glycero-D-galacto-non-2-enoic Acids (KDN2en) and Its C-4 Nitrogen-modifying Derivatives. Carbohydr. Res. 2000, 323, 1-6.
19. Xue-Long Sun, T. Kai, H. Takayanagi, and K. Furuhata, A Straightforward Synthesis of ¿-Furyl Amide via Lewis Acid-mediated Allylic Substitution. SYNLETT 1999, (9), 1399-1341.
18. Xue-Long Sun, T. Kai, N. Sato, H. Takayanagi, and K. Furuhata, Synthesis of 4-Oxo- and 4-Hydroxyimino-KDN2en Derivatives. J. Carbohydr. Chem. 1999, 18, 1131-1138.
17. Xue-Long Sun, T. Kai, H. Takayanagi, and K. Furuhata, Synthesis of Sialic Acid Analogs with the Acylamino Groups at C-4 (N-Acyl Regioisomers of Sialic Acids). Carbohydr. Res. 1997, 298, 181-189.
16. Xue-Long Sun, T. Kai, M. Tanaka, H. Takayanagi, and K. Furuhata, Synthesis of 2,6-Anhydro-3-deoxy-D-glycero-D-galacto-non-2-enoic Acids (KDN2en) and its Hydrogenation Products. J. Carbohydr. Chem. 1997, 16, 541-547.
15. T. Kai, Xue-Long Sun, H. Takayanagi, and K. Furuhata, Oxidation Products of C-4 and C-7 Hydroxyls into the Methyl ¿-Glycoside Derivatives of KDN. J. Carbohydr. Chem. 1997, 16, 533-540.
14. T. Kai, Xue-Long Sun, Takayanagi, and K. Furuhata, Synthesis of Sialic Acid Analogs with the Oxime Groups at C-4 or C-5 of KDN. J. Carbohydr. Chem. 1997, 16, 521-532.
13. Xue-Long Sun, T. Kai, M. Takayanagi, and K. Furuhata, A Novel Glycosylation of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acids. Chem. Pharm. Bull. 1996, 45, 795-798.
12. Xue-Long Sun, H. Takayanagi, K. Matsuzaki, H. Tanaka, K.Furuhata, and S. Omura, Synthesis and Inhibitory Activities of Isochromophilone Analogues against gp120-CD4 binding. J. Antibiotics, 1996, 49, 689-692.
11. T. Kai, Xue-Long Sun, M. Tanaka, H. Takayanagi, and K. Furuhata, Reaction products from Fisher's Methylation of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN). Chem. Pharm. Bull. 1996, 44, 208-211.
10. M. Tanaka, T. Kai, Xue-Long Sun, H. Takayanagi, and K. Furuhata, Synthesis of N-Glycosyl-8-O-Sulfoneuraminic Acid. Chem. Pharm. Bull. 1995, 43, 2095-2098.
9. M. Tanaka, T. Kai, Xue-Long Sun, H. Takayanagi, and K. Furuhata, Synthesis of Fluorescent 4-Methyl-7-Thiocoumaryl S-Glycosides of Sialic Acid. Chem. Pharm. Bull. 1995, 43, 1844-1848.
8. Xue-Long Sun, T, Kai, M. Tanaka, H. Takayanagi, K. and Furuhata, A Facile Synthesis of 4-Acylamino-2,6-anhydro-2,3,4-trideoxy-D-glycero-D-galacto-non-2-enoic Acids. Chem. Pharm. Bull. 1995, 43, 1654-1658.
7. S-S, Li, Xue-Long Sun, H. Ogura, Y. Konda, T. Sasaki, Y. Toda, H. Takayanagi, and Y. Harigaya, Photocycloaddition of Benzoylated 2'-Deoxyribo-nucleoside to 2,3-Dimethyl-2-butene. Chem. Pharm. Bull. 1995, 43, 144-146.
6. Y. Konda, T. Sasaki, Xue-Long Sun, X. Li, M. Onda, H. Takayanagi, and Y. Harigaya, Conformational Analysis of C3'-C8 Connected Biflavones. J. Heterocyclic Chem. 1995, 32, 1531-1535.
5. Xue-Long Sun, N. Haga, H. Ogura, and H. Takayanagi, Synthesis of ¿-N-Glycoside of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN) using Nucleobase and Their Photocycloaddition to 2,3-Dimethyl-2-butene. Chem. Pharm. Bull. 1994, 42, 2352-2356.
4. Y. Konda, T. Sasaki, Xue-Long Sun, X. Li, M. Onda, H. Takayanagi, and Y. Harigaya, Absolute Structure of 2'-Desacetoxyaustrospicatine Established by X-Ray Analysis and Circular Dichroism Spectroscopy. Chem. Pharm. Bull. 1994, 42, 2621-2624.

Peer-Reviewed Publications at Shenyang Pharmaceutical University:
3. Xue-Long Sun, L. -J. Wu, X. Li, Y. Konda, and M. Onda, Chemical Studies of Tuxus cuspidata Sieb et Zucc. Chin. J. Med. Chem., 1992, 2, 31-34.
2. Xue-Long Sun and X. Li, Recent Chemical Studies on Pine Leaf Components. J. ShenYang. Pharm. Univ, 1991, 8, 145-149.
1. Y. Harigaya, Y. Konda, M. Iguchi, M. Onda, X. Li, L. J. Wu, S. S. Li, and Xue-Long Sun, Spectroscopic Studies of Brusatol J. Nat. Prod. 1989, 52, 740-748